Anti-Aging & Longevity
Ipamorelin
Also known as: Growth hormone secretagogue (GHS)
A five-amino-acid peptide that stimulates growth hormone release through the ghrelin receptor, noted in early work for being more selective than older compounds.
Overview
Ipamorelin is a small synthetic peptide that binds the ghrelin receptor and triggers the pituitary gland to release growth hormone. Early reports described it as selective, meaning it raised growth hormone without much effect on stress hormones such as cortisol.
What the research has looked at
Animal and early human studies measured growth hormone release. A clinical trial tested it for recovery of bowel function after surgery, but that trial did not show clear benefit.
What we do not know
- There is no strong clinical evidence for benefits in healthy adults.
- Long-term effects of repeated growth hormone stimulation are not established.
- It is often sold in blends with other peptides, which have not been studied as combinations.
Regulatory context
Ipamorelin is not an approved medicine, and it is prohibited in sport.
Related pages
See also CJC-1295, Sermorelin and Tesamorelin.
References & further reading
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561.
Educational reference only. Not medical advice. This page does not recommend or describe human use, dosing or sourcing.