Weight Loss & Metabolic
AOD-9604
Also known as: hGH fragment 176-191 (modified), Tyr-hGH 177-191
A lab-made fragment of human growth hormone that was developed as an obesity treatment, but did not show meaningful weight loss in clinical trials.
Overview
AOD-9604 is a short peptide built from the tail end of human growth hormone, with a tyrosine added to the front. The idea was to keep growth hormone's effect on fat metabolism without its other hormonal effects.
What the research has looked at
Early animal studies reported reduced fat gain and effects on fat breakdown. The compound then moved into human trials for obesity, and was later explored in research on joint cartilage.
What we do not know
- Human obesity trials did not show clinically meaningful weight loss, and development for that purpose was not pursued further.
- Evidence for other uses is limited and mostly early-stage.
- Long-term safety has not been established.
Regulatory context
AOD-9604 is not an approved medicine. It appears on the World Anti-Doping Agency prohibited list, so it matters for competitive athletes.
Related pages
See the Peptide A-Z for other compounds studied for metabolic effects.
References & further reading
Educational reference only. Not medical advice. This page does not recommend or describe human use, dosing or sourcing.